Bioce is a method based on Bayesian statistics that infers conformational ensembles from a pre-generated structural models and experimental Small Angle Scattering data (SAXS or SANS).

The first stage of the method involves a fast model selection approach based on variational Bayesian inference that maximizes the model evidence of the selected ensemble. This is followed by a complete Bayesian inference of population weights in the selected ensemble.

To infer conformational ensemble from SAS data: Upload your files

The method is also avaialable as a standalone tool. Installation instructions, documentation and running examples can be found at: Bioce website

The decription of the algorithms used in the method can be found in the paper: Potrzebowski et al. PLoS Computational Biology. 14, 12, e1006641. Dec 2018) Read the paper

For more info, documentation and source code please go to: Github repo